DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. The safety and efficacy of bupropion for smoking cessation is not established in children or adolescents. Children 6 years and older with a major depressive episode or attention-deficit hyperactivity disorder (ADHD) have been studied in clinical trials of bupropion, but data regarding pediatric safety are limited. Bupropion comes as a tablet and a sustained-release or extended-release (long-acting) tablet to take by mouth. The regular tablet (Wellbutrin) is usually taken three times a day, with doses at least 6 hours apart, or four times a day, with doses at least 4 hours apart. Wellbutrin received an overall rating of 6 out of 10 stars from 1367 reviews. See what others have said about Wellbutrin, including the effectiveness, ease of use and side effects. Here's a list of some common side effects reported with this medicine, how ever from my own experience i can tell you that most of them if not all will gradually disappear over time, more so some will never appear at all.: WARNING: AND SUICIDAL THOUGHTS AND BEHAVIORS SUICIDALITY AND ANTIDEPRESSANT DRUGS Although Zyban is not indicated for treatment of depression, it contains the same active ingredient as the antidepressant medications WELLBUTRIN ®, WELLBUTRIN ® SR, and WELLBUTRIN XL® Amlodipine besylate causes vasodilation, or dilation of the blood vessels. The increased blood flow to the arms and legs can lead to side effects. Major Depressive Disorder. Wellbutrin XL ® (bupropion hydrochloride extended-release tablets) is indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). Loss of appetite is a common side effect of fluoxetine. MayoClinic.com explains that appetite-related complications of fluoxetine are not medically urgent but should be reported to a physician if loss of appetite becomes severe or troublesome. I took Sam-e for about a year while back and found it very helpful. It had no side effects except that I had almost too much energy. You have to think about it--if you have been depressed and now have energy, you need to have a plan to develop the social skills and goals to channel that energy, and get your life on track.